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Septrin dosage iv on human erythrocytes.
METHODS:
A systematic literature search was conducted using the keywords "paracetamol" and phrases "dose in blood", "dextrose placebo", and "oral/skin/subcutaneous." Erythrocyte contents were determined by fluorescence microscopy. For oral administration, paracetamol tablets were dissolved, and blood was removed. For skin application, paracetamol tablets were dissolved in 1-3 mL of 100% ethanol and placed on the skin.
RESULTS:
In a clinical experiment, 1 or 5 mg of acetaminophen oral/subcutaneous or ethanol-soluble tablet was administered in 50% dextrose. The mean plasma levels of paracetamol (PAP) after 30 minutes of administration were: 15 ± 3 pg/mL for dextrose, 15 ± 3–18 pg/mL for 50% ethanol, and 0 ± mg/mL for 10%, depending on the tablet. After an hour average amount of acetaminophen was 7 ± 1 mg per day [0.6 g/day (75)], which was comparable with the level found 2 hours after ingestion in a patient who had ingested one
Actoplus met 120 Pills $196 - $179 Per pill tablet of dextrose. The dextrose-soluble contained a higher amount of paracetamol than the ethanol-soluble tablets, and dextrose tablet also contained a considerable amount of other active ingredients, which could not be detected in the ethanol-soluble tablet. A similar clinical study by Japanese laboratory was performed in which paracetamol oral and ethanol-soluble tablets were administered orally or applied on skin. For both oral and skin delivery, significant elevations of a number paracetamol metabolites were present, and the mean total concentration was 7 ± 1% of the concentration found after oral administration of 50% dextrose. The mean PAP values were significantly different (p < 0.001) in both studies. The study of Matsumoto et al.; reported in the Journal of Clinical Chemistry concluded that the mean concentration of paracetamol in plasma increased with increasing oral dosage [mean: 9 ± 3 mg per day (81)].
CONCLUSION:
After oral administration in the patient with renal disease, PAP were found to be higher than when the patient was placed on a dry actoplus met xr coupon skin surface. Thus these results suggest that paracetamol administration over an extended period of time to a dry surface may be way of prolonging the amount available in circulation of oral therapeutic agents such as acetaminophen.
